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Historian Glenn Johnson said it was a "sensitive aetiological site" and must be developed to keep the original architectural features.

Most early epidemiological work entailed case-control studies, which look at the medical history, lifestyle and history of environmental exposures to potential aetiological agents of people with cancer compared with healthy individuals from a selected population.

Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus.

Structure-based classification will enable aetiological and epidemiological studies to evaluate comprehensively the connection between prion strains that cause disease in humans with those that cause disease in animals.

Emerging functional data are also shifting the aetiological focus of the disease from a neuron-centric view to an integrated outlook that acknowledges the synergistic functions of the different cell types of the brain9.