AMANTADINE Definition & Meaning

amantadine

[ uh-man-tuh-deen ]

Phonetic (Standard)IPA

noun

Pharmacology.

a water-soluble crystalline substance, C 10 H 17 NHCl, used as an antiviral and antiparkinsonian drug.

amantadine

/ əˈ��æ�Գ�əˌ�徱ː�� /

noun

an antiviral drug used in the treatment of some types of influenza and to reduce some of the symptoms of Parkinson's disease

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51�Թ� History and Origins

Origin of amantadine¹

1960–65; coinage apparently based on the chemical name 1-aminoadamantane; amino-, adamantane

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51�Թ� History and Origins

Origin of amantadine¹

C20: a blend of amine + adamantane the chemical compound from which it is derived

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Example Sentences

Examples have not been reviewed.

What’s more, the flu virus has developed resistance to oseltamivir and to an older drug, amantadine.

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His main approach has been to target the mutation in the M2 channel that created resistance to amantadine and rimantadine.

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Amantadine blocks the process by which viral RNA is released into the host cell, and the mutation provides a new channel through which the virus can release its RNA.

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Nearly all the viruses in circulation around the globe had a mutation that rendered amantadine and rimantadine — the two adamantanes used to treat flu, which work by blocking a particular step in viral replication — completely useless.

From

Extended-release amantadine, taken daily, has been shown to reduce the total daily OFF time but does not convert an OFF episode into ON time.

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