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There was bone cancer, chemo and red blood cell aplasia that left him needing regular transfusions.

Paul, 14, was born with what the family assumes is amniotic band syndrome, while Jesse, 8, and Eddie, 4, were born with bilateral radial aplasia.

With most of his skin missing, except for on his head, he was initially diagnosed with aplasia cutis, a rare congenital absence of skin.

Evidence for on-target toxicity included B cell aplasia as well as decreased numbers of plasma cells and hypogammaglobulinemia.