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In addition, the study provides evidence that deficiency of apolipoprotein E, a protein involved in lipid metabolism results in a signature of accelerated endothelial aging.

It picked up the well-known association between Alzheimer's and high cholesterol, through a variant form of the apolipoprotein E gene, APOE4.

Advanced age and carrying the apolipoprotein ε4 risk gene are already known risk factors.

It encodes the protein apolipoprotein E, which is involved in fat and cholesterol metabolism.

In another experiment, we used the tau mouse model, which also expressed human APOE4, to test whether reducing levels of the apolipoprotein variant would protect against neurodegeneration.