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The balance of negative and positive signals in maintaining an appropriate B cell activation threshold is critical in B lymphocyte immune tolerance and autoreactivity.

Benlysta, which is given as an intravenous infusion every 28 days, is a monoclonal antibody that curbs the immune system by inhibiting a protein in the body called B lymphocyte stimulator.

The drug, which would be given by intravenous infusion every four weeks, is a monoclonal antibody that tamps down the immune system by inhibiting a protein in the body called B lymphocyte stimulator.