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Notably, the biguanide sensitivity of cancer cells with mtDNA mutations was reversed by ectopic expression of yeast NDI1, a ubiquinone oxidoreductase that allows bypass of complex I function.

Similarly, cell lines with impaired glucose utilization exhibit biguanide sensitivity specifically under the low glucose conditions seen in the tumour microenvironment.

Similarly, cell lines with impaired glucose utilization exhibit biguanide sensitivity specifically under the low glucose conditions seen in the tumour microenvironment.

Similarly, cell lines with impaired glucose utilization exhibit biguanide sensitivity specifically under the low glucose conditions seen in the tumour microenvironment.

When the researchers delivered an even higher dose of metformin, this time by injection, the tumor burden shrank by 72 percent, says study coauthor Phillip Dennis of the National Cancer Institute in Bethesda, Md. Metformin is a drug in the biguanide class.