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Boundary, border, frontier share the sense of that which divides one entity or political unit from another. Boundary, in reference to a country, city, state, territory, or the like, most often designates a line on a map: boundaries are shown in red. Occasionally, it also refers to a physical feature that marks the agreed-upon line separating two political units: The Niagara River forms part of the boundary between the United States and Canada. Border is more often used than boundary in direct reference to a political dividing line; it may also refer to the region (of, for instance, a country) adjoining the actual line of demarcation: crossing the Mexican border; border towns along the Rio Grande. Frontier may refer to a political dividing line: crossed the Spanish frontier on Tuesday. It may also denote or describe the portion of a country adjoining its border with another country ( towns in the Polish frontier ) or, especially in North America, the most remote settled or occupied parts of a country: the frontier towns of the Great Plains. Frontier, especially in the plural, also refers to the most advanced or newest activities in an area of knowledge or practice: the frontiers of nuclear medicine.