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Pytho's world changes when Alexander dies and Aristotle, concerned about growing anti-Macedonian sentiment in Athens, moves his family to the more rustic Chalcis.

There he wrote the greater part of his works, the completion of some of which was stopped by his death at Chalcis in 322.

The Achaean and Aetolian Leagues are independent powers, which the Macedonian can indeed check by garrisons in Corinth, Chalcis and elsewhere, but which keep a field clear for Hellenic freedom within their borders.

Greece and Peloponnesus; central Greece appears to have been protected against them by the fortress-square of Chalcis, Thebes, Corinth and Athens.

The rebel—his name was Baanes—was put down, but meanwhile Antioch, Chalcis, and all Northern Syria fell into the hands of the Arabs.