CONSTANT REGION Definition & Meaning

constant region

The portion of the amino acid sequence of an antibody's heavy or light chains that determines the class of the antibody and does not vary within a given class. The constant region terminates in a free carboxyl group (COOH). Unlike the variable region, the constant region does not interact with antigens.
Compare variable region

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Example Sentences

Examples have not been reviewed.

The FG loop structure5 of TCRβ’s constant region controls the lifetime of a TCR–pMHC bond and also the extension of the TCRαβ heterodimer when it transitions from a compact to an extended form under force during antigen recognition6,9.

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Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes.

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constant region

Example Sentences