51Թ

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dedifferentiation

[ dee-dif-uh-ren-shee-ey-shuhn ]

noun

Biology.
  1. a process by which structures or behaviors that were specialized for a specific function lose their specialization and become simplified or generalized.


dedifferentiation

/ 徱ːˌɪəˌɛʃɪˈɪʃə /

noun

  1. the reversion of the cells of differentiated tissue to a less specialized form
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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51Թ History and Origins

Origin of dedifferentiation1

First recorded in 1915–20; de- + differentiation ( def )
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Example Sentences

Examples have not been reviewed.

Instead, differentiated cells undergo what is known as dedifferentiation after the removal of the growth zone.

From

This reduction in neural selectivity, or dedifferentiation, is linked to worsening memory performance.

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Such cellular dedifferentiation in the absence of Rb has also been observed in prostate cancer5.

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Her team has discovered that cardiac progenitors from neonates, but not adults, seem to proliferate better under these microgravity conditions, and that they show signs of dedifferentiation—reverting back to a more primitive, unspecialized state.

From

Although still a controversial idea, many scientists now think that regeneration is driven by a process known as dedifferentiation.

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