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"Initially we hypothesized that more tumor EV-DNA would mean a worse prognosis, but we were surprised to find the opposite," said study co-senior author Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology and a professor of Pediatrics and of Cell and Developmental Biology at Weill Cornell Medicine.

"We have developed an efficient biological approach to reverse insecticide resistance without creating any other perturbation to the environment," said Bier, a professor in the Department of Cell and Developmental Biology, of the self-eliminating allelic drive, or "e-Drive."

"We show that our approach correctly classifies the functions of previously characterized genes, identifies functions for poorly characterized genes and describes new gene and pathway relationships," said Oegema, a faculty member in the Department of Cell and Developmental Biology and the paper's senior author.

Over his long career, Manny Ares, UC Santa Cruz distinguished professor of molecular, cellular, and developmental biology, has made it his mission to learn as much about RNA splicing as he can.

By studying the developmental biology of metabolism and how it differs in autism, new insights are emerging in ASD and other complex developmental disorders.