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A metabolic disease characterized by abnormally high levels of glucose in the blood, caused by an inherited inability to produce insulin (Type 1) or an acquired resistance to insulin (Type 2). Type 1 diabetes, which typically appears in childhood or adolescence, is marked by excessive thirst, frequent urination, and weight loss and requires treatment with insulin injections. Type 2 diabetes appears during adulthood, usually in overweight or elderly individuals, and is treated with oral medication or insulin. People with either type of diabetes benefit from dietary restriction of sugars and other carbohydrates. Uncontrolled blood glucose levels increase the risk for long-term medical complications including peripheral nerve disease, retinal damage, kidney disease, and progressive atherosclerosis caused by damage to endothelial cells in blood vessels, leading to coronary artery disease and peripheral vascular disease.