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dornase alfa
[ dawr-neys al-fuh, -neyz ]
- a genetically engineered form of recombinant human DNase that reduces the viscosity of mucus in the lungs, especially in the treatment of cystic fibrosis.
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51³Ô¹Ï History and Origins
Origin of dornase alfa1
First recorded in 1980–85; shortening and alteration of (recombinant human) d(e)o(xy)r(ibo)n(ucle)ase (1) + alpha ( def )
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Example Sentences
Examples have not been reviewed.
In people with cystic fibrosis—an inherited disease that causes persistent lung infections—a medication called dornase alfa that breaks up NETs by cleaving DNA can loosen sputum and relieve symptoms.
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Additional trials are testing other NET-targeting agents —such as dornase alfa and drugs approved for rheumatoid arthritis and gout—in patients hospitalized for COVID-19.
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