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In exceptional instances the intensity of the poison is such that the system fails to rally before the violence of the onset, and a fatal result ensues before the characteristic exanthem appears upon the skin.

Occurring at about the dates named above, it is in a few patients pronounced and vivid, even in solitary instances rivalling in severity the exanthem which succeeds it.

None of these flash-light warnings of the oncoming exanthem are proportioned to the latter in the matter of extent and intensity of development.

Upon its subsidence the exanthem of the disease as a rule promptly appears.

The initial lesions of the exanthem are dense and deeply-set papules, so closely coherent even at this moment that they scarcely leave between them interspaces of sound skin.