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In two-thirds of these patients fibrinolysis was delivered prior to hospital arrival– a high rate made possible by the common presence of physicians in French ambulances.

We report that endothelial lamellipodia surround emboli within hours of occlusion, markedly reducing hemodynamic washout and tissue plasminogen activator–mediated fibrinolysis in mice.

Sobel was among the most powerful and influential cardiologists in the 1980s when he played a key early role in the development of fibrinolysis and the first major biotechnology product, TPA.

Fibrinolysis patients underwent angiography at 6-24 hours or, if fibrinolysis was unsuccessful, immediately.