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Using the wealth of data in this study and collaborating with co-author Stefano Forli, PhD, associate professor in the Department of Integrative Structural and Computational Biology, the authors then modeled how certain molecules might bind to these proteins.

The mayor of nearby Forli, Gian Luca Zattini, said his city was "on its knees, devastated and in pain", AFP news agency reported.

RAI public television and other media said at least four people were unaccounted for, one in Cesena and three in nearby Forli.

Reinforcements for the rescuers were moved in from the cities of Forli’-Cesena, Ferrara and Bologna.

He took a serpentine path from Beantown to Tinseltown: the 3,000-mile trip snaked through New Hampshire, Sardinia, Israel, the Italian cities of Ostuni, Trieste, Siena, Verona and Forli, and several other towns too obscure to mention.