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For a continent-sized, soccer-crazed country that would normally be sharing a collective dream for the hexa — a historic sixth title — the bid for the global championship is raising a deeply personal question.

Tay-Sachs is a severe neurological disease caused by a deficiency in an enzyme called HexA.

Without HexA, however, this fatlike substance can accumulate to toxic levels that damage and kill neurons.

The only effective way to treat Tay-Sachs is to restore the HexA enzyme in the brain.

In the case of Tay-Sachs, these DNA instructions enter the nucleus of these cells and stay there, allowing for long-term production of HexA.