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For example, heavy drug use has been linked to smaller overall brain sizes, and heavy cannabis consumption has been linked to smaller hippocampal volumes.

In this study, substance use was linked to larger overall brain sizes and larger hippocampal volumes.

"Now accessible on hippocampushub.eu, this model serves as a flexible tool for scientists, providing extensive analyses and an interface to support further hippocampal research."

However, since exercise impacts the brain and body in many different ways, it wasn't clear whether the effect of exercise was due to hippocampal circuit rewiring by neurogenesis, or other factors.

Next the team will tackle the mouse hippocampal formation, which is important to neuroscience for its role in memory and neurological disease.