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Another experimental drug, imipramine, was supposedly an antipsychotic, but scientists discovered in 1957 that it worked much better on people with depression.

Traditionalists claim that antidepressants, especially older ones such as imipramine, work only for melancholic depression.

But he would be dancing at the edge of science to put suicidal patients on Prozac, while patients with melancholic depression may in fact do quite well on older agents such as imipramine.

On mice with late-stage tumours that had spread throughout the brain, though, imipramine had little effect.

The new reanalysis revealed that neither Paxil nor high-dose imipramine was more effective than a placebo in the treatment of major depression in adolescents.