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In first clinical studies, researchers have injected precursors of dopaminergic neurons into the striatum, to try and make up for the lost natural innervation.

Interestingly, Zhang et al. found that the propensity of an area to turn grey correlates with its level of sympathetic innervation.

NGF-deficient mice have pronounced disruption of sympathetic innervation of multiple peripheral tissues7, but BAT innervation has not been specifically examined in this context.

“They had improved shape, size, bone, innervation, and function.”

Organs and tissues need effective vascular, lymphatic and innervation networks, but these are not part of the current design template; nor do they have enough time to develop organically before the transplant organ dies.