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To further confirm this result, the researchers suppressed MeSC proliferation pharmacologically and genetically.

When proliferation was dampened, the effects of stress on MeSC proliferation, differentiation and migration were blocked.

However, when the researchers tracked MeSCs labelled with a fluorescent protein, they discovered that MeSC proliferation and differentiation increase markedly under extreme stress or exposure to a high level of noradrenaline.

For instance, is the mechanism underlying MeSC depletion in response to stress the same as that which causes greying during ageing?

In both cases, greying occurred after stress, indicating that neither corticosterone nor autoimmune reactions cause MeSC depletion.