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Liz is a compelling creation, at once smart, sassy and wily, and there is fun to be had watching her slickly outwit credulous individuals.

Unlike Harry and co, who would perform hair-raising manoeuvres while soaring through the air on broomsticks, real-life players try to outwit their opponents astride PVC pipes.

The market they created was basically a bunch of guys trading stuff and trying to make money by outwitting each other in their private marketplace.

But they are increasingly facing a crafty adversary: bacteria that mutate and adapt and outwit the very drugs designed to defeat them and cure the infections they cause.

Armed with their new knowledge, the team hopes to outwit bacteria by cutting off multiple pathways.