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Umbaugh perfected a process of "super-ovulation"�injecting the cows with a pituitary extract which causes them to produce an average of 23 ova.

Injections of pituitary extract directly into the blood stream were tried at first, but they caused disagreeable reactions.

Scientific research into the pituitary was not pushed until the 1920s, when Herbert McLean Evans of the University of California caused rats to become giants by injecting them with crude pituitary extract.

Their patient told them that his great-grandfather had spells over 100 years ago, had passed them on to 27 descendants, now spread all over the U. S. In an effort to discover the cause of his attacks, the doctors gave the young man a dozen different drugs, from common salt to pituitary extract, doused him in tubs of hot and cold water, sent him running up & down 15 flights of stairs.

The scientists experimented with dogs, gave some of them injections of anterior pituitary extract until their islets were worn out and their insulin content very low.