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They pinpointed a particular population of cells that may provide protection against brain injury and a drug that can activate these cells, which they tested in preclinical models.

In preclinical in vivo studies, the material showed remarkable results: it fully repaired bone defects within 3-6 months and even triggered the formation of a new layer of strong, healthy cortical bone in 4 weeks.

Smith Charitable Trust Distinguished Professor in Cancer Research -- and his lab have successfully tested a new immune therapy that, in preclinical lab testing, reliably improves survival and reduces tumor burden in glioblastoma.

"Cell therapy has encountered substantial barriers in both preclinical studies and clinical trials, but the field continues to progress and evolve through lessons learned from such research."

In the new paper, the researchers detail preclinical studies using mRNA as a therapeutic in the eye.