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Something like estimated 75% of all cases of prefrontal lobotomy in the 1940s and '50s were women, and many of those women were older.

A paint factory boasts a state-of-the-art hospital with a machine capable of executing a noninvasive equivalent of a prefrontal lobotomy.

Psychosurgery, notoriously prefrontal lobotomy, also has a tragic history of abuse.

He is trenchant on psychiatry’s failures, from prefrontal lobotomy to ‘care in the community’; critical of neuro-reductionism; eloquent on diagnosis debates; and ever aware of the human suffering at his chronicle’s core.

Much of Shriver’s motivation came from the fate of older sister Rosemary, who spent her final 63 years in an institution after a disastrous prefrontal lobotomy left her incapacitated at age 23.