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Hapna’s affordability and touted lack of side effects led to its global usage, followed by Skinner’s sudden disappearance.

The aggressive shift in trade policy makes clear where Trump stands on tariffs, but has left much of the world wondering what Americans - who are expected to see the side effects - think of the move.

“Vaccines are medicines, and all medicines have side effects — even when the net benefit is large,” observes Adam Gaffney, a Harvard medical school assistant professor who has been critical of the study.

King Charles has attended his first public engagement since side effects from his cancer treatment stopped him carrying out a visit last Friday.

The King spent a short period of time in hospital in London last Thursday after suffering "temporary side effects" from his cancer treatment, with a visit to Birmingham having to be postponed.