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In a statement, Dr. Jonathan Mermin, the director of CDC's National Center for HIV, Viral Hepatitis, STD and TB Prevention said he saw a “glimmer of hope amidst millions of STIs.”

The new guideline is specific to gay and bisexual men and transgender women who had an STD in the previous year and are at high risk of getting infected again.

On Thursday night in front of a packed house it involved a lot of World War II references, stories of legendary STD scares and his not-so-secret disdain for his children.

Helicopters Mulaney cracked several one-liners about the episode’s aviation theme , calling a chopper circling an STD billboard “the official bird of Los Angeles.”

The billboard directs viewers to a link where they can find out more about free STD testing.