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To examine the effect of nanocapsules with the lactate oxidase enzyme, the team tested the approach in mice with melanoma and triple-negative breast cancer and performed tumor growth measurement, survival curve analysis, RNA sequencing, and immune cell population analysis.

Non-parametric two-tailed Kolmogorov–Smirnov test; NS, not significant. d, Kaplan–Meier survival curve of human embryos following microinjection of Cas9 protein or sgRNA2b–Cas9 ribonucleoprotein complex.

Non-parametric two-tailed Kolmogorov–Smirnov test; NS, not significant. d, Kaplan–Meier survival curve of human embryos following microinjection of Cas9 protein or sgRNA2b–Cas9 ribonucleoprotein complex.

“We want more durable responses and more people at the tail end of the survival curve. I'm less excited about improving median survival ... than I am about seeing more patients in remission and off drug treatment.”

It permits their oncologist to open up new conversations that don’t include the latest million-dollar blockbuster therapy with a bleak survival curve but do mention the therapeutic benefit of teaming up with hospice workers to write letters, preserve photos and record memories.