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“Even if you could download the information that a brain holds, the trillions of synaptic connections unique to each brain ... Those synapses are constantly changing,” Shepherd said.

"This study represents one of the first direct visualizations showing the localization of these two proteins on synaptic vesicle membranes," she explains.

However, misprocessing of APP, due to altered mechanical cues, disrupts this pathway, leading to the synaptic degeneration observed in Alzheimer's and could explain the memory loss associated.

Another likely possibility is physiological strength of those connections, which is established by a myriad of factors like the amount of neurotransmitter being released, the type of synaptic receptors and the concentration of those receptors.

Part II, published in eLife alongside the first paper, describes the physiology of the brain region and how it was modeled and validated at the synaptic, neuronal and network-level.