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In people, the inherited liver disease that the scientists targeted in mice, called hereditary tyrosinemia type 1, starts damaging the liver months before birth.

Mice that have been genetically modified to develop hereditary tyrosinemia, a human liver disease, will resist the disease if they also lose another gene on chromosome 16 called homogentisic acid dioxygenase.

The Philadelphia scientists then tried their technique on hereditary tyrosinemia type 1.