51�Թ�

Fumarate and succinate, for example, are formed as intermediate products in the mitochondria of cells.

Now, a team at HZB led by Prof. Alexander Föhlisch has elucidated the influence of the electronic structure on the stability of fumarate, maleate and succinate dianions.

The analysis of the spectral data shows that maleate is potentially less stable than fumarate and succinate.

The Recovery trial currently has experiments under way in more than 38,000 patients on five drugs: aspirin; colchicine, a gout treatment; a COVID-19-targeted antibody cocktail made by Regeneron Pharmaceuticals; baricitinib, which treats rheumatoid arthritis; and dimethyl fumarate, a treatment for multiple sclerosis,” Kupferschmidt writes.

The trial has randomized more than 38,000 participants and is testing five drugs: aspirin; colchicine, a gout treatment; a COVID-19–targeted antibody cocktail made by Regeneron Pharmaceuticals; baricitinib, which treats rheumatoid arthritis; and dimethyl fumarate, a treatment for multiple sclerosis.